Research topic:

Role of Fibroblast Growth Factors (FGFs) in hepatic fibrosis

In this project, which is funded by the German Research Association (DFG), we investigate the role of Fibroblast Growth Factors (FGFs) in the development and progression of liver fibrosis. The focus lies on Fibroblast Growth Factor 7 (FGF7) also called Keratinocyte Growth Factor (KGF) and its receptor Fibroblast Growth Factor Receptor 2 IIIb (FGFR2IIIb).

In diseased livers FGF7 is specifically expressed by activated hepatic stellate cells (HSC) while FGFR2IIIb is exclusively expressed by hepatocytes