Research topic:

Molecular mechanisms of pharmacological effects of hop constituents

The focus of these studies lies on Xanthohumol, the principle prenylchalcone of the hop plant Humulus lupulus L, and they are funded by the Barth-Haas Group.

We have already shown that Xanthohumol inhibits hepatic inflammation and fibrosis as well as the tumorigenicity of HCC cells. Currently, we are working on the identification of the underlying mechanisms of these hepatoprotective effects. Further, we study the metabolisms as well as the bioavailability of Xanthohumol, which are widely unknown.


Hop
Xanthohumol

In addition to Xanthohumol we expand our research to other hop constituents as bitter acids, and pharmacologically effective compounds of other plants as in Salix and Arnica on basic mechanisms of wound healing and fibrosis.